Spinal cord injury and circadian disruption: 2 of 2

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Dr. Gaudet published paper 2 of 2 on spinal cord injury-induced circadian disruption in Journal of Neurotrauma. This paper reveals that spinal cord injury disrupts crucial rhythms of metabolic function – even far away from the injury site – including peripheral glucose oscillations, glucose machinery mRNA in liver, and circadian rhythms in fecal output. These discoveries highlight new directions for improving spinal cord injury-elicited metabolic dysfunction.

Spinal cord injury and circadian disruption: 1 of 2

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Dr. Gaudet published paper 1 of 2 on spinal cord injury-elicited circadian disruption in eNeuro. This was a collaboration completed with colleagues at the University of Colorado Boulder. The manuscript shows for the first time that spinal cord injury disrupts various measures of circadian rhythms, including body temperature, activity, and corticosterone. These results could have implications for post-injury treatment, from acute-to-chronic phases. The paper has received press coverage! See here and here.